775-657-8844

Lali Sekhon, MD, PhD, FACS

Anterior Lumbar Fusion

Lumbar Anatomy

The lower back or lumbar spine is composed of 5 bones, called vertebrae and the sacrum. Each vertebrae is connected to each adjacent vertebrae by 3 joints, 1 at the front (anteriorly) and 2 at the back (posteriorly). The joint at the front is called an intervertebral disc and is a common cause of surgical pathology. The joints at the back are called facet joints and are present as pairs straddling the midline. In addition to these 3 joints and bony structures, there are numerous ligaments and muscles. One of the more important ligaments is called the ligamentum flavum.  This yellow ligament bridges between adjacent vertebrae and can thicken with age and cause compression of nerves. The spinal cord sits inside a bony tunnel in the posterior half of each vertebrae which is called the spinal canal. The ligamentum flavum lines the back half of this canal. The back half of the spinal canal is formed by wing shaped pieces of bone called laminae. At each level, 2 lamina united and form a spinous process which is like a midline keel of bone and can be felt in the midline through the skin in the back. Holes at regular levels on each side of the spinal canal form intervertebral foramina. Each foramen allows 1 nerve to exit and in the lumbar spine there are 5 on each side. The spinal cord finishes at the lower border of the first lumbar vertebra and then becomes a leash of nerves (the cauda equina). Below this point only nerves are present and no spinal cord is present. Consequently most surgery on the lower back is on and around nerves rather than spinal cord. The spinal nerves in the lumbar spine supply strength in the legs, sensation from the groin down and bladder and bowel function. Injury to one nerve may cause no problem or may affect some or all of the previously mentioned modalities.
image002
image004

Definition

Fusion literally translates “to join” and in spine surgery this means that 2 vertebrae are joined together to make one. There are many reasons why one would perform a fusion (see below) but in essence the surgeons endeavors to trick the body into thinking that the two bones to be fused are a single bone that has broken and then sets up the right conditions so that in healing the bones heal as one. Just as if you broke your arm, 2 bones with sticky ends would become one. In the arm’s case, a plaster cast is applied to hold things in place until the bones are healed, typically 6 weeks. In the lower back screws, plates, rods, cages and an external brace take the place of the plaster cast, and full fusion occurs after 3 months. The “sticky ends” in the case of the spine are the roughened surfaces of bone. Typically bone graft, usually the marrow, is taken from the hip and placed between the roughened surfaces. Nowadays bone morphogenic protein can enhance fusions by stimulating bone growth. When bone healing occurs, new bone comes out of the roughened surfaces and migrates along the transplanted bone to bridge the area to be fused. Ironically, at 6-12 months all the transplanted bone or BMP has been replaced by new bone. Understanding all of the above, it becomes clear that although there are a lot of screws and hardware involved, the operation essentially joins bone to bone and it takes a full 12 months to heal. In all my patients they cannot smoke for 1 month prior and 3 months after the surgery as the healing rate of the bone (i.e. the success of the fusion) drops from 90% to 40-50%. Similarly NSAIDs such as Celebrex or Mobic must not be taken for 3 months after surgery as they also reduce the fusion rate by 20%.

Anatomy

Looking at the anatomy section, fusions are typically done in one of 3 places. The typical fusion is a posterolateral fusion where bone is placed in the bony gutters between the transverse processes. This is the commonest fusion done and involves a large amount of muscle dissection. Interbody fusions involve the removal of the whole intervertebral disc and bone chips or cages are placed into the cavity. These can be done from in front or behind. This is a fusion that is technically more demanding to perform but has a higher fusion rate and, for technical reasons, is more versatile. Facet joint fusi are usually done to supplement interbody fusions and involve the removal of the facet joint capsule and packing the joint with bone graft.
image003 

Reason For Operation

Anterior lumbar interbody fusions (ALIFs) are essentially performed for back pain that is thought to be coming from the discs. The workup for this is quite extensive and patients need to have failed conservative therapy for at least 6 months. The type of pain may be mechanical, meaning that it is worse when you bend forward and the there may be leg pain.

In terms of diagnosing the cause of pain an MR scan (see below where all the discs look normal except the lowest one) and a discogram is typically performed.
image005

A discogram is an invasive study that looks for a pain generator. A pain specialist under local anesthesia places needles into 3 or 4 discs spaces. He then puts saline into each one in turn. A positive result produces pain at the same disc that is abnormal on the MR scan and this is said to be concordant. If more than 1-2 are positive that's not good. Ideally only one or perhaps two should be painful. A normal disc should cause no pain. The type of pain produced is also important. It should be close to or exactly like the bad pain that is trying to be addressed. If it is significantly different that is not a good prognosticator.

Typical discogram results are shown below:
CIMG1899

Technique

In order to perform the surgery a general surgeon is utilized to perform the anterior exposure. This is because the biggest risk from the procedure is injury to the big vessels that go to and come from the legs and the general surgeon moves the abdominal organs and vessels out of the way. The picture below shows the typical anatomy before and after an exposure.
image007  image009

Once the disc space is exposed the disc space is then cleaned out by the spine surgeon. surgeon. The back of the disc is not usually removed so the nerves are not seen. I then place a plastic cage into the space full of BMP and place a plate on the front. A one level case takes about an hour. 2 levels take between 2 and 3 hours. Below are xrays showing how a before and after.Note the height of the disc before and after surgery:
pre        post

BMP (Bone Morphogenic Protein)
Bone morphogenic protein (BMP) is a substance commonly used when fusion surgery is done that is synthetically produced and stimulates bone growth. BMP is commonly used in all manner of fusion surgery and has reduced the incidence of fusions not taking as well as reducing the need to take bone graft from the top of the hip bone.

For years, scientists have been searching for ways to stimulate the human body to generate and repair bone more reliably and more quickly.  No one appreciates the importance of such research more than the spinal surgeon.  More than half of the thousands of bone fusion operations performed annually in the United States involve fusion of the spinal column.  Traditionally, spinal fusion requires the transplant of bone chips from a patient’s pelvis to the spinal vertebrae to help “fuse” them together.  Although this procedure can be very effective for the treatment of certain spinal disorders, the bone transplantation procedure (bone grafting) can prolong surgery, increase blood loss, increase hospital stay, increase recovery time, and increase recovery pain.  Moreover, the bone grafting technique does not always reliably result in successful fusion of the vertebrae because of occasional inadequate bone growth.

Recently, scientists and spinal surgeons have demonstrated that a genetically produced protein, recombinant human bone morphogenetic protein-2, or rhBMP-2, has the ability to stimulate a patient’s own cells to make more bone.  This finding has obvious beneficial implications for the treatment of many bone fractures and bone defects.  More importantly, though, rhBMP-2 can be tremendously beneficial to patients undergoing spinal fusion.  It will eliminate the need for bone transplantation from the pelvis.  It may more reliably and more quickly produce fusion of spinal vertebrae.  It may even reduce the need for the implantation of spinal rods and screws.

The process of stimulating bone growth within the body is known as osteoinduction.  One of the pioneers in the science of osteoinduction was Dr. Marshall Urist, Professor Emeritus of the Department of Orthopaedic Surgery at the UCLA school of Medicine.  More than 35 years ago, Dr. Urist discovered that the proteins that directed bone to heal itself were contained within its own matrix, or substance.  It was not until 1988 that these proteins were individually identified and genetically reproduced.  Thereafter, it was quickly discovered that rhBMP-2 could, by itself, direct the repair and regeneration of bone in various parts of the skeleton.  In several laboratory experiments performed from 1993 to 1997, rhBMP-2 was shown to effectively stimulate bone growth along spinal vertebrae.

 In 1997, rhBMP-2 was used for the first time in patients undergoing spinal fusion.  In this initial clinical trial, all eleven patients who had been implanted with rhBMP-2 achieved successful fusion within 6 months from the time of surgery.  In fact, 10 of these 11 patients had achieved their fusions within 3 months of surgery.  Because theses patients did not require bone grafting from the pelvis, their hospital stays were shorter and their post-surgical pain was less than typically seen with the traditional bone grafting techniques.  These promising initial findings are now being studied in several larger clinical trials throughout the United States.

There is little doubt that powerful biologic proteins such as rhBMP-2 will eventually help all surgical specialists treat a variety of common as well as complex spinal disorders.  These osteoinductive factors will enable surgeons to modify their techniques to minimize the invasiveness of their operations.  Ultimately, the goal will be reduce the pain associated with surgery and recovery, improve the effectiveness of the surgical treatments, and hasten the return of patients to productive and healthy lifestyles.

RhBMP-2 has recently received clearance from the Food and Drug Administration (FDA) for specific uses.

Risks

There are 3 types of risks from this surgery:

  1. Exposure complications: this is the commonest and most serious and this is why a general/vascular surgeon does the exposure. Anything from damage to the abdominal contents to injury to the blood vessels can occur and although uncommon can be life-threatening and require a blood transfusion
  2. Disc/nerve complications: Generally the fusion rate is 95%. It drops in smokers and those with immune suppression such as kidney failure. Occasionally new neurological symptoms can develop after this surgery which may be due to stretching of nerves.
  3. General complications: pneumonia, clots in the legs, infections etc can happen in all patients. These are all higher in obese patients and diabetics.


The overall complication rate is less than 5% but no guarantees can be made.

Expectations

It is difficult to look at likely success rates when the indications for surgery are quite varied. This is something that the surgeon will discuss with the patient prior to surgery. As a rule of thumb there is about a 70% chance of some improvement in back pain symptoms which can range from complete relief to not as many bad attacks.

Recovery

My patients spend 2-4 nights in hospital. This operation is not as sore as one done from the back but it may take some time for the bowels to get working again. Patients are mobilized in a lumbar brace (which is basically a support for the lower back and is worn like a girdle) every time they are out of bed for a total of 3 months. At discharge all my patients do is walk. They do not bend, lift, twist or sit for prolonged periods of time. Bending and lifting are particularly bad as they can lead to screw breakage and failure of fusion. Physical therapy is not started for 12 weeks after surgery although in hospital the therapist will teach you how to get out of bed and do your daily activities. Patients are reviewed 2 weeks after surgery, then at 6 weeks, 3 months, 6 months and 1 year with x-rays. Typically I advise my patients not to rub any creams on the incision and to keep it dry. Bathing is to be avoided, as is swimming but showering is OK. It is important that the wound is allowed to heal. Any signs of redness, discharge, swelling, etc. etc. needs to be reviewed by a doctor.   Typical x-rays showing a solid fusion of the spine are shown below:

post

 

As stated in the introduction to this section, it is important not to smoke or take NSAIDs for 3 months after surgery as bone healing is occurring.  Good back care is the rule for life after this surgery as, and this must be stressed, the back has not been returned to normal after a fusion.

Non-Surgical Options

An ALIF is not a small operation. Just as in lumbar discectomy there are non-operative options that include any or all of the following and these should be aggressively pursued to try and expedite improvement in symptoms:

Conservative therapy comprises

  • Analgesia with NSAIDs (e.g. Mobic, Voltaren or Celebrex)
  • Analgesia with other medications such as Tramadol
  • Avoidance of bending/lifting/twisting/sitting for prolonged periods
  • Physical therapy
  • Hydrotherapy
  • Cortisone blocks
  • Possibly acupuncture
  • Weight loss
  • Exercise
  • Bracing


Other Points

Fusing 2 bones puts stress on adjacent levels and this can accelerate wear and tear at these levels. This is important as patients can develop symptoms months or years later, which may require further surgery. The anterior approach seems to have less of this than the posterior approach as the muscles and joints of the back are not disturbed.

Lumbar Anatomy

The lower back or lumbar spine is composed of 5 bones,

called vertebrae and the sacrum. Each vertebrae is

connected to each adjacent vertebrae by 3 joints, 1 at

the front (anteriorly) and 2 at the back (posteriorly).

The joint at the front is called an intervertebral disc

and is a common cause of surgical pathology. The joints

at the back are called facet joints and are present as

pairs straddling the midline. In addition to these 3

joints and bony structures, there are numerous ligaments

and muscles. One of the more important ligaments is

called the ligamentum flavum.  This yellow ligament

bridges between adjacent vertebrae and can thicken with

age and cause compression of nerves. The spinal cord

sits inside a bony tunnel in the posterior half of each

vertebrae which is called the spinal canal. The

ligamentum flavum lines the back half of this canal. The

back half of the spinal canal is formed by wing shaped

pieces of bone called laminae. At each level, 2 lamina

united and form a spinous process which is like a

midline keel of bone and can be felt in the midline

through the skin in the back. Holes at regular levels on

each side of the spinal canal form intervertebral

foramina. Each foramen allows 1 nerve to exit and in the

lumbar spine there are 5 on each side. The spinal cord

finishes at the lower border of the first lumbar

vertebra and then becomes a leash of nerves (the cauda

equina). Below this point only nerves are present and no

spinal cord is present. Consequently most surgery on the

lower back is on and around nerves rather than spinal

cord. The spinal nerves in the lumbar spine supply

strength in the legs, sensation from the groin down and

bladder and bowel function. Injury to one nerve may

cause no problem or may affect some or all of the

previously mentioned modalities.

Definition

Fusion literally translates “to join” and in spine

surgery this means that 2 vertebrae are joined together

to make one. There are many reasons why one would

perform a fusion (see below) but in essence the surgeons

endeavors to trick the body into thinking that the two

bones to be fused are a single bone that has broken and

then sets up the right conditions so that in healing the

bones heal as one. Just as if you broke your arm, 2

bones with sticky ends would become one. In the arm’s

case, a plaster cast is applied to hold things in place

until the bones are healed, typically 6 weeks. In the

lower back screws, plates, rods, cages and an external

brace take the place of the plaster cast, and full

fusion occurs after 3 months. The “sticky ends” in the

case of the spine are the roughened surfaces of bone.

Typically bone graft, usually the marrow, is taken from

the hip and placed between the roughened surfaces.

Nowadays bone morphogenic protein can enhance fusions by

stimulating bone growth. When bone healing occurs, new

bone comes out of the roughened surfaces and migrates

along the transplanted bone to bridge the area to be

fused. Ironically, at 6-12 months all the transplanted

bone or BMP has been replaced by new bone. Understanding

all of the above, it becomes clear that although there

are a lot of screws and hardware involved, the operation

essentially joins bone to bone and it takes a full 12

months to heal. In all my patients they cannot smoke for

1 month prior and 3 months after the surgery as the

healing rate of the bone (i.e. the success of the

fusion) drops from 90% to 40-50%. Similarly NSAIDs such

as Celebrex or Mobic must not be taken for 3 months

after surgery as they also reduce the fusion rate by

20%.

Anatomy

Looking at the anatomy section, fusions are typically

done in one of 3 places. The typical fusion is a

posterolateral fusion where bone is placed in the bony

gutters between the transverse processes. This is the

commonest fusion done and involves a large amount of

muscle dissection. Interbody fusions involve the removal

of the whole intervertebral disc and bone chips or cages

are placed into the cavity. These can be done from in

front or behind. This is a fusion that is technically

more demanding to perform but has a higher fusion rate

and, for technical reasons, is more versatile. Facet

joint fusi are usually done to supplement interbody

fusions and involve the removal of the facet joint

capsule and packing the joint with bone graft.
 
Reason For Operation

Anterior lumbar interbody fusions (ALIFs) are

essentially performed for back pain that is thought to

be coming from the discs. The workup for this is quite

extensive and patients need to have failed conservative

therapy for at least 6 months. The type of pain may be

mechanical, meaning that it is worse when you bend

forward and the there may be leg pain.

In terms of diagnosing the cause of pain an MR scan (see

below where all the discs look normal except the lowest

one) and a discogram is typically performed.

A discogram is an invasive study that looks for a pain

generator. A pain specialist under local anesthesia

places needles into 3 or 4 discs spaces. He then puts

saline into each one in turn. A positive result produces

pain at the same disc that is abnormal on the MR scan

and this is said to be concordant. If more than 1-2 are

positive that's not good. Ideally only one or perhaps

two should be painful. A normal disc should cause no

pain. The type of pain produced is also important. It

should be close to or exactly like the bad pain that is

trying to be addressed. If it is significantly different

that is not a good prognosticator.

Typical discogram results are shown below:

Technique

In order to perform the surgery a general surgeon is

utilized to perform the anterior exposure. This is

because the biggest risk from the procedure is injury to

the big vessels that go to and come from the legs and

the general surgeon moves the abdominal organs and

vessels out of the way. The picture below shows the

typical anatomy before and after an exposure.

Once the disc space is exposed the disc space is then

cleaned out by the spine surgeon. surgeon. The back of

the disc is not usually removed so the nerves are not

seen. I then place a plastic cage into the space full of

BMP and place a plate on the front. A one level case

takes about an hour. 2 levels take between 2 and 3

hours. Below are xrays showing how a before and

after.Note the height of the disc before and after

surgery:

BMP (Bone Morphogenic Protein)
Bone morphogenic protein (BMP) is a substance commonly

used when fusion surgery is done that is synthetically

produced and stimulates bone growth. BMP is commonly

used in all manner of fusion surgery and has reduced the

incidence of fusions not taking as well as reducing the

need to take bone graft from the top of the hip bone.

For years, scientists have been searching for ways to

stimulate the human body to generate and repair bone

more reliably and more quickly.  No one appreciates the

importance of such research more than the spinal

surgeon.  More than half of the thousands of bone fusion

operations performed annually in the United States

involve fusion of the spinal column.  Traditionally,

spinal fusion requires the transplant of bone chips from

a patient’s pelvis to the spinal vertebrae to help

“fuse” them together.  Although this procedure can be

very effective for the treatment of certain spinal

disorders, the bone transplantation procedure (bone

grafting) can prolong surgery, increase blood loss,

increase hospital stay, increase recovery time, and

increase recovery pain.  Moreover, the bone grafting

technique does not always reliably result in successful

fusion of the vertebrae because of occasional inadequate

bone growth.

Recently, scientists and spinal surgeons have

demonstrated that a genetically produced protein,

recombinant human bone morphogenetic protein-2, or

rhBMP-2, has the ability to stimulate a patient’s own

cells to make more bone.  This finding has obvious

beneficial implications for the treatment of many bone

fractures and bone defects.  More importantly, though,

rhBMP-2 can be tremendously beneficial to patients

undergoing spinal fusion.  It will eliminate the need

for bone transplantation from the pelvis.  It may more

reliably and more quickly produce fusion of spinal

vertebrae.  It may even reduce the need for the

implantation of spinal rods and screws.

The process of stimulating bone growth within the body

is known as osteoinduction.  One of the pioneers in the

science of osteoinduction was Dr. Marshall Urist,

Professor Emeritus of the Department of Orthopaedic

Surgery at the UCLA school of Medicine.  More than 35

years ago, Dr. Urist discovered that the proteins that

directed bone to heal itself were contained within its

own matrix, or substance.  It was not until 1988 that

these proteins were individually identified and

genetically reproduced.  Thereafter, it was quickly

discovered that rhBMP-2 could, by itself, direct the

repair and regeneration of bone in various parts of the

skeleton.  In several laboratory experiments performed

from 1993 to 1997, rhBMP-2 was shown to effectively

stimulate bone growth along spinal vertebrae.

 In 1997, rhBMP-2 was used for the first time in

patients undergoing spinal fusion.  In this initial

clinical trial, all eleven patients who had been

implanted with rhBMP-2 achieved successful fusion within

6 months from the time of surgery.  In fact, 10 of these

11 patients had achieved their fusions within 3 months

of surgery.  Because theses patients did not require

bone grafting from the pelvis, their hospital stays were

shorter and their post-surgical pain was less than

typically seen with the traditional bone grafting

techniques.  These promising initial findings are now

being studied in several larger clinical trials

throughout the United States.

There is little doubt that powerful biologic proteins

such as rhBMP-2 will eventually help all surgical

specialists treat a variety of common as well as complex

spinal disorders.  These osteoinductive factors will

enable surgeons to modify their techniques to minimize

the invasiveness of their operations.  Ultimately, the

goal will be reduce the pain associated with surgery and

recovery, improve the effectiveness of the surgical

treatments, and hasten the return of patients to

productive and healthy lifestyles.

RhBMP-2 has recently received clearance from the Food

and Drug Administration (FDA) for specific uses.
Risks

There are 3 types of risks from this surgery:

1. Exposure complications: this is the commonest and

most serious and this is why a general/vascular surgeon

does the exposure. Anything from damage to the abdominal

contents to injury to the blood vessels can occur and

although uncommon can be life-threatening and require a

blood transfusion

2. Disc/nerve complications: Generally the fusion rate

is 95%. It drops in smokers and those with immune

suppression such as kidney failure. Occasionally new

neurological symptoms can develop after this surgery

which may be due to stretching of nerves.

3. General complications: pneumonia, clots in the legs,

infections etc can happen in all patients. These are all

higher in obese patients and diabetics.

The overall complication rate is less than 5% but no

guarantees can be made.

Expectations

It is difficult to look at likely success rates when the

indications for surgery are quite varied. This is

something that the surgeon will discuss with the patient

prior to surgery. As a rule of thumb there is about a

70% chance of some improvement in back pain symptoms

which can range from complete relief to not as many bad

attacks.

Recovery

My patients spend 2-4 nights in hospital. This operation

is not as sore as one done from the back but it may take

some time for the bowels to get working again. Patients

are mobilized in a lumbar brace (which is basically a

support for the lower back and is worn like a girdle)

every time they are out of bed for a total of 3 months.

At discharge all my patients do is walk. They do not

bend, lift, twist or sit for prolonged periods of time.

Bending and lifting are particularly bad as they can

lead to screw breakage and failure of fusion. Physical

therapy is not started for 12 weeks after surgery

although in hospital the therapist will teach you how to

get out of bed and do your daily activities. Patients

are reviewed 2 weeks after surgery, then at 6 weeks, 3

months, 6 months and 1 year with x-rays. Typically I

advise my patients not to rub any creams on the incision

and to keep it dry. Bathing is to be avoided, as is

swimming but showering is OK. It is important that the

wound is allowed to heal. Any signs of redness,

discharge, swelling, etc. etc. needs to be reviewed by a

doctor.   Typical x-rays showing a solid fusion of the

spine are shown below:

As stated in the introduction to this section, it is

important not to smoke or take NSAIDs for 3 months after

surgery as bone healing is occurring.  Good back care is

the rule for life after this surgery as, and this must

be stressed, the back has not been returned to normal

after a fusion.

Non-Surgical Options

An ALIF is not a small operation. Just as in lumbar

discectomy there are non-operative options that include

any or all of the following and these should be

aggressively pursued to try and expedite improvement in

symptoms:

Conservative therapy comprises

Analgesia with NSAIDs (e.g. Mobic, Voltaren or Celebrex)
Analgesia with other medications such as Tramadol
Avoidance of bending/lifting/twisting/sitting for

prolonged periods
Physical therapy
Hydrotherapy